Kisspeptin-10 Research Peptide (known chemically as metastin 45-54 or KISS1 112-121 fragment) is the shortest fully functional C-terminal amidated decapeptide fragment of the human KISS1 gene precursor. Comprising 10 amino acids (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2), Kisspeptin-10 functions as the primary endogenous ligand for the G-protein coupled receptor KISS1R (formerly known as GPR54).
Positioned at the apex of the neuroendocrine hierarchy, Kisspeptin-10 acts as the master upstream regulator of the hypothalamic-pituitary-gonadal (HPG) axis. By binding KISS1R on arcuate and anteroventral periventricular (AVPV) hypothalamic neurons, Kisspeptin-10 triggers synchronized, pulsatile secretion of Gonadotropin-Releasing Hormone (GnRH). This upstream pulse drives the downstream synthesis and pituitary release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).
Kisspeptin-10 | Molecular Identity & Composition
| Name | Kisspeptin-10 |
| Synonyms | Kisspeptin-10, Kp-10, Metastin (45-54), KISS1 (112-121), YNWNSFGLRF-NH2 |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| Molecular Formula | C63H83N17O14 |
| Molecular Weight | 1302.45 g/mol |
| CAS Number | 374675-21-5 |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile water or bacteriostatic water |
| Purity | ≥99% (HPLC) |
| Storage Guidelines | • Lyophilized: ≤0°F (–18°C), dry, protected from light • Reconstituted: 36–46°F (2–8°C); avoid repeat freeze–thaw • Long-Term: Keep dry and frozen until use |
Ellixon Bio Quality Advantage
- Purity & Identity: ≥99% | HPLC & MS validated
- Endotoxin & Sterility: <0.05 EU/mg | Third-party verified
- Stability & Process: Controlled nucleation lyophilization | Stability-focused procedures
- Formulation & QA: PhD-Formulated | GMP / ISO-Aligned manufacturing
- Packaging: Luxe Fridge-Ready Box
Category Overview | Antioxidant & Cellular Signaling
Signal transduction peptides are used in RUO studies to explore how cells send and receive messages. These tools help map GPCR activation, downstream cascades, and stress-adaptive responses.
Research Use Disclaimer
This product is supplied for laboratory research use only (RUO) and is intended solely for qualified professionals in a controlled research setting. It is not a drug, food, dietary supplement, cosmetic, or medical device, and is not intended for human or veterinary use or for any diagnostic, therapeutic, or clinical application. It is not for household use.
No statement on this page has been evaluated by the U.S. Food and Drug Administration. Nothing herein is intended to diagnose, treat, cure, or prevent any disease, nor to suggest any dosage, route, or method of administration. Ellixon Bio makes no representation or warranty, express or implied, regarding fitness for any purpose other than research and provides no medical or professional advice. The purchaser and end user assume full responsibility for safe handling, storage, and use in accordance with all applicable laws, regulations, and institutional safety protocols, and accept all associated risk and liability.
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