ARA-290 (also designated Cibinetide) is a research use only (RUO) synthetic peptide of eleven amino acids, engineered from the Helix B surface domain of Erythropoietin (EPO). The sequence reproduces the solvent-facing face of that helix — the region proposed to mediate EPO’s non-hematopoietic receptor interactions — while omitting the structural determinants associated with classical Erythropoietin Receptor (EPOR) homodimer signaling.
In cell-culture and preclinical model systems, ARA-290 is studied as a selective ligand for the Innate Repair Receptor (IRR), described in the literature as a heterodimer of EPORand the Beta-Common Receptor (CD131). Because the parent hormone engages both the EPOR homodimer and the EPOR/CD131 heterodimer, ARA-290 gives researchers a way to isolate the heterodimeric arm of that signaling system and study it independently of full-length EPO.
ARA-290 | Molecular Identity & Composition
| Peptide Name | ARA-290 (Cibinetide) |
| Synonyms | Cibinetide · ARA290 · pHBSP · Helix B Surface Peptide (HBSP) |
| CAS Number | 1208243-50-8 |
| Molecular Formula | C51H84N16O21 |
| Molecular Weight | ≈1257.32 g/mol |
| Sequence (Three-Letter) | Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH |
| Sequence (One-Letter) | pGlu-EQLERALNSS |
| Chain Length | 11 Amino Acids |
| PubChem CID | 91810664 |
| Parent Molecule | Erythropoietin (EPO), Helix B Surface Domain |
| Reported Target | Innate Repair Receptor (IRR) — EPOR/CD131 Heterodimer |
| Appearance | White To Off-White Lyophilized Powder |
| Purity | ≥99% (HPLC) |
| Storage | Lyophilized: -20°C, Protected From Light · Reconstituted: 2-8°C, Short Term |
Ellixon Bio Quality Advantage
- Purity: ≥99% verified by HPLC on every batch
- Identity: Confirmed by Mass Spectrometry (MS)
- Net Peptide Content: Verified with replicate testing
- Sterility: Tested per batch
- Endotoxin: <0.05 EU/mg
- Fentanyl Screening: Performed on every batch
- PhD-Formulated · Third-Party Verified · GMP/ISO-Aligned Manufacturing
Category Overview | Signal Transduction Pathways
Signal Transduction peptides are studied in RUO settings to map how a defined ligand engages a defined receptor complex and which downstream cascades follow. Receptor-selective analogs are especially useful here: when a native hormone engages more than one receptor assembly, a shorter engineered sequence that favors one assembly lets researchers separate signaling arms that would otherwise be observed together.
Peptides in this category are commonly paired with phosphorylation readouts, reporter assays, and receptor-subunit knockdown or blockade to establish which receptor components are required for a given in vitro response.
Exciting Areas of Study
- Receptor-Heterodimer Engagement And Subunit-Dependence Modeling
- JAK2/STAT3 And PI3K/Akt Cascade Activation In Cultured Cells
- Cytokine-Marker Profiling In Inflammation-Related Cell Models
ARA-290 | Research Modeling & Applications
- Model Innate Repair Receptor (EPOR/CD131) engagement in cultured cells
- Compare heterodimer-selective vs. full-length Erythropoietin signaling in vitro
- Benchmark concentration–response across JAK2/STAT3 and PI3K/Akt reporters
- Test CD131 subunit dependence using knockdown or receptor-blockade controls
- Profile inflammation-related cytokine markers in cell-culture model systems
Research Use Disclaimer
This product is supplied for laboratory research use only (RUO) and is intended solely for qualified professionals in a controlled research setting. It is not a drug, food, dietary supplement, cosmetic, or medical device, and is not intended for human or veterinary use or for any diagnostic, therapeutic, or clinical application. It is not for household use.
No statement on this page has been evaluated by the U.S. Food and Drug Administration. Nothing herein is intended to diagnose, treat, cure, or prevent any disease, nor to suggest any dosage, route, or method of administration. Ellixon Bio makes no representation or warranty, express or implied, regarding fitness for any purpose other than research and provides no medical or professional advice. The purchaser and end user assume full responsibility for safe handling, storage, and use in accordance with all applicable laws, regulations, and institutional safety protocols, and accept all associated risk and liability.
See our Terms & Conditions and our Research Compliance Disclaimers for complete terms.
