LL-37 is a 37-residue cationic amphipathic peptide derived from the C-terminal domain of human cathelicidin hCAP18, used in RUO models to study innate immune signaling, host–pathogen membrane interactions, TLR modulation, and immunomodulatory pathway dynamics. Typical assays include antimicrobial membrane disruption profiling, TLR2/TLR4 inhibition studies, FPRL1/FPR2 receptor engagement, and angiogenic/wound-response pathway mapping. Not intended for diagnostic or therapeutic use.
- TLR2/TLR4 ligand neutralization and innate immune modulation assays
- Membrane-active antimicrobial mechanism and pore-formation modeling
- FPRL1/FPR2 receptor engagement and downstream signaling profiling
LL-37 | Molecular Identity & Composition
| Name | LL-37 |
| Synonyms | CAP-18; hCAP18; Cathelicidin; Ropocamptide; Antibacterial Peptide LL-37; CAMP peptide |
| Sequence | H-Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH |
| Molecular Formula | C205H340N60O53 |
| Molecular Weight | ~4,493.34 g/mol |
| CAS Number | 154947-66-7 |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile or bacteriostatic water; buffer-dependent — ionic strength and pH affect activity in assay systems |
| Purity | ≥99% (HPLC), lot-specific |
| Storage Guidelines | • Lyophilized: ≤0°F (–18°C), dry, protected from light • Reconstituted: 36–46°F (2–8°C); avoid repeat freeze–thaw • Long-Term: Keep dry and frozen until use |
Ellixon Bio Quality Advantage
- Purity & Identity: ≥99% | HPLC & MS validated
- Endotoxin & Sterility: <0.05 EU/mg | Third-party verified
- Stability & Process: Controlled nucleation lyophilization | Stability-focused procedures
- Formulation & QA: PhD-Formulated | GMP / ISO-Aligned manufacturing
- Packaging: Luxe Fridge-Ready Box
Category Overview | Innate Immunity & Antimicrobial Peptides
Innate immunity peptides are used in RUO studies to explore how the body’s first-line defense systems detect, respond to, and regulate threats at the cellular and molecular level. These peptides help researchers model host–pathogen interfaces, TLR-mediated signaling cascades, and the dual roles antimicrobial peptides play in both direct pathogen clearance and immunomodulation. Lab models using these tools aim to better understand how cationic host defense peptides coordinate inflammation, membrane activity, and tissue repair signaling.
Exciting Areas of Study
- How cationic peptides disrupt bacterial membranes and interfere with LPS/LTA function in lab models.
- Peptide-driven modulation of TLR2, TLR4, TLR7, and TLR9 signaling in innate immune assays.
- Dual pro- and anti-inflammatory roles of host defense peptides under varying conditions.
- Model angiogenic and wound-response pathway activation via FPRL1/FPR2 engagement in vitro.
- Map TLR-mediated innate immune activation and suppression under peptide exposure
LL-37 | Research Modeling & Applications
- Interrogate thiol-disulfide dynamics and antioxidant capacity
- Map redox-sensitive signaling under controlled stressors
- Benchmark enzyme-coupled glutathione pathways in vitro
Research Use Disclaimer
This product is supplied for laboratory research use only (RUO) and is intended solely for qualified professionals in a controlled research setting. It is not a drug, food, dietary supplement, cosmetic, or medical device, and is not intended for human or veterinary use or for any diagnostic, therapeutic, or clinical application. It is not for household use.
No statement on this page has been evaluated by the U.S. Food and Drug Administration. Nothing herein is intended to diagnose, treat, cure, or prevent any disease, nor to suggest any dosage, route, or method of administration. Ellixon Bio makes no representation or warranty, express or implied, regarding fitness for any purpose other than research and provides no medical or professional advice. The purchaser and end user assume full responsibility for safe handling, storage, and use in accordance with all applicable laws, regulations, and institutional safety protocols, and accept all associated risk and liability.
See our Terms & Conditions and our Research Compliance Disclaimers for complete terms.
